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Nutrition 207

Laboratory 4- 20 Jan 2011

Atherosclerosis

Pre-lab lecture-atherosclerosis pathology

                                              With clinically significant                           Without clinically significant

                                                  atherosclerotic disease                          atherosclerotic disease

-plasma triglycerides                            450                                                           100

-plasma cholesterol                              300                                                           150

-plasma HDL-cholesterol                      20                                                             50

-plasma LDL-cholesterol                     190                                                             80

-plasma LDL size(angstroms)              250                                                           270

-plasma Lp(a)                                        50                                                            1                      

-plasma VLDL-cholesterol                     90                                                            20                    

-plasma chylomicrons-triglyceride            80                                                            54

            (4 hours post-prandial)

-blood pressure(mm Hg)                       180/100                                               110/80

-height

-weight

-BMI(kg/m2)                                        35                                                           22

-waist circumference(cm)                     110                                                          60

-platelet reactivity bleeding time             2.5                                                         6.0

(minutes)

 all lipid or lipoprotein-lipid levels are mg/dl plasma and represent fasting values except where noted otherwise

 


 

Introduction

Why are waist circumference, blood lipid and lipoprotein concentrations, blood pressure and platelet reactivity of significance in human atherosclerosis?

Hypothesis

What would one hypothesise to be the differences in waist circumference, blood lipid and lipoprotein concentrations, blood pressure and platelet reactivity between the 2 groups and why?

Objective

Methods

How does one measure waist circumference, blood lipid and lipoprotein concentrations, blood pressure and platelet reactivity?

Results

What are the differences in waist circumference, blood lipid and lipoprotein concentrations, blood pressure and platelet reactivity between the 2 groups and indicate the correlation between waist circumference and each of  blood lipid and lipoprotein concentrations, blood pressure and platelet reactivity within each of  the 2 groups?

Discussion

Explain the results.

Conclusions

What would one conclude about differences in waist circumference, blood lipid and lipoprotein concentrations, blood pressure and platelet reactivity between the 2 groups?